Mechanism of action of Acetaminophen

Mechanism of action of Acetaminophen
Inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center.

Indications of Acetaminophen

1. Analgesic-antipyretic in patients with aspirin allergy, hemostatic disturbances, bleeding diatheses, upper GI disease, gouty arthritis
2. Arthritis and rheumatic disorders involving musculoskeletal pain (but lacks clinically significant antirheumatic and anti- inflammatory effects)
3. Common cold, "flu," other viral and bacterial infections accompanied by pain and fever
4. Unlabeled use: prophylactic for children receiving DPT vaccination to reduce incidence of fever and pain

Contraindications of Acetaminophen

1. Contraindicated in the presence of allergy to acetaminophen.
2. Use caution in the presence of impaired hepatic function, chronic alcoholism, pregnancy, lactation.