Mechanism of action of Diclofenac

Mechanism of action of Diclofenac
Inhibits prostaglandin synthetase to cause antipyretic and anti-inflammatory effects; the exact mechanism of action is not known.

Indications of Diclofenac

1. Acute or long-term treatment of mild to moderate pain, including dysmenorrhea
2. Rheumatoid arthritis
3. Osteoarthritis
4. Ankylating spondylitis

Contraindications of Diclofenac

1. Contraindicated in the presence of significant renal impairment, pregnancy, lactation.
2. Use caution in the presence of impaired hearing, allergies, hepatic,
   cardiovascular, and GI conditions.

Adverse effects of Diclofenac

• CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthamologic effects
• GI: Nausea, dyspepsia, GI pain, vomiting, constipation, flatulence
• Hematologic: Bleeding, platelet inhibition with higher doses
• GU: Dysuria, renal impairment
• Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
• Other: Peripheral edema, anaphylactoid reactions to fatal anaphylactic shock