Mechanism of action of ibuprofen

Mechanism of action
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.

Indications

1. Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
2. Relief of mild to moderate pain
   Treatment of primary dysmenorrhea
3. Fever reduction
4. Unlabeled use: treatment of juvenile rheumatoid arthritis

Contraindications

1. Presence of allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps)
2. Cardiovascular dysfunction
3. Hypertension
4. Peptic ulceration
5. GI bleeding
6. Pregnancy
7. Lactation

Use caution in the presence of impaired hepatic or renal function.