Mechanism of action of aluminum carbonate gel
Neutralizes or reduces gastric acidity, resulting in an increase in the pH of the stomach and duodenal bulb and inhibiting the proteolytic activity of pepsin, which protects the lining of the stomach and duodenum; binds with phosphate ions in the intestine to form insoluble aluminum-phosphate complexes, lowering phosphate in hyperphosphatemia and chronic renal failure but may cause hypophosphatemia in other states.
Indications
- Symptomatic relief of upset stomach associated with hyperacidity
- Hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, gastric hyperacidity, hiatal hernia
- Treatment, control, or management of hyperphosphatemia-aluminum carbonate
- Prevention of formation of phosphate urinary stones, used in conjunction with a low-phosphate diet-aluminum carbonate
- Unlabeled use for aluminum hydroxide: prophylaxis of GI bleeding, stress ulcer; reduction of phosphate absorption in hyperphosphatemia in patients with chronic renal failure
Contraindications/cautions
- Allergy to aluminum products
- Gastric outlet destruction
- Hypertension
- CHF
- Hypophosphatemia
- Lactation
Adverse effects of aluminum carbonate gel
- GI: Constipation; intestinal obstruction, decreased absorption of fluoride, accumulation of aluminum in serum, bone, and CNS
- MS: Osteomalacia and chronic phosphate deficiency with bone pain, malaise, muscular weakness
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